Natural Estrogen Management Supplement for Men on TRT

 Natural Estrogen Management Supplement for Men on TRT

In our Last article called How to Lower Estrogen in Men on Testosterone Replacement Therapy / TRT we covered some of side effects of high estrogen levels in men on TRT, Some of the medicines used (Aromatase Inhibitors) to lower estrogen levels in men on TRT and some of the side effects of these estrogen lowering medicines.

We briefly touched on the fact that mother nature may have a few tricks up her sleeve when it comes to helping to manage estrogen for both men and women. But in this article we will cover natural estrogen lowering supplements in the context of men on testosterone replacement therapy.

Let's cover some of these awesome natural supplements that have been clinically shown to help manage estrogen levels for men on TRT and also some of their other natural benefits.

Diindolylmethane (DIM)

DIM is well known in the TRT community and is probably the most widely used estrogen management supplement taken by guys on TRT who are looking to manage their estrogen levels without the use of an AI.

DIM is found naturally in many cruciferous vegetables like Broccoli, Cabbage, Brussel Sprouts and Cauliflower. You would need to eat two pounds of broccoli to get 20mg of DIM.

DIM does not actually block testosterone conversion to estrogen. DIM is believed to speed up your bodies natural metabolism for estrogen.

Some research shows DIM increases the level of "favorable" estrogens (2-hydroxyestrogen) while reducing the level of "less favorable" estrogens (16-hydroxyestrogen).


  • Helps prevent the effects of estrogen on cells
  • Slows some cancer cells
  • Lowers toxins produced by your body’s natural metabolism
  • Boosts antioxidants
  • Promotes weight loss
  • Enhances memory
  • Improves mood
  • Supports cardiovascular health
  • Promotes good muscle development
  • Improves prostate health for men

Calcium D-Glucarate

Calcium D-Glucarate is the salt and the commercial form of glucaric acid, which occurs naturally in a variety of foods including apples, oranges, broccoli, and spinach.

Calcium D-Glucarate has been shown to help speed up the process of removing toxins in the body. In one study, calcium-d-glucarate was able to reduce the number of estrogen receptors by 48 percent.  It’s also been shown to lower serum estrogen levels by 23 percent.

It has also been shown to reduce LDL levels which is of concern if you are on TRT as testosterone has been shown to raise LDL levels.


  • Supports liver detoxification
  • Potentially inhibits some types of cancer
  • Helps maintain already healthy cholesterol levels

Indole-3-Carbinol (I3C)

Indole-3-carbinol is formed from a substance called glucobrassicin found in vegetables such as broccoli, Brussels sprouts, cabbage, collards, cauliflower, kale, mustard greens, turnips, and rutabagas. I3C actually breaks down into DIM in the body, but not before helping to reduce estrogen and possibly having anti cancer properties.

I3C has been shown to improve Phase I detoxification of estrogens favoring the less potent 2OH estrone pathway.

I3C has been shown to exhibit potent anticarcinogenic properties in a wide range of cancers such as lung, liver, colon, cervical, endometrial, prostate, and breast cancer.

Grape Seed Extract (Vitas Vinifera)

Grape Seed Extract is exactly what its name suggests. It's basically ground up grape seeds. Grape seed extract (GSE) contains high levels of procyanidin dimers that have been shown to be potent inhibitors of aromatase. In one study, GSE was found to inhibit aromatase activity in a dose-dependent manner.


  • Reduce blood pressure
  • Improve blood flow
  • Reduce oxidative damage
  • Improve collagen levels and bone strength
  • Improve kidney function
  • Protect your liver
  • Enhance wound healing

Natural Estrogen Management Supplements for Men on TRT

As you can see these four separate natural supplements show a lot of promise for helping men to manage estrogen levels while on testosterone replacement therapy. Not only do they provide the estrogen management benefit, but they also offer many other health benefits such as Reduced Blood Pressure, Anticarcinogenic Properties, Help maintain healthy cholesterol levels, Promote weight loss and many other possible health benefits.

Imagine being able to take a natural supplement that helped to manage your estrogen levels, while also providing health benefits? Imagine not having to worry about something like Arimidex or Aromasin eating away at your bones and negatively effecting your cholesterol levels? In our eyes it is a win win!

No AI Natural Estrogen Management Supplement

We created No AI as the worlds first natural estrogen management supplement specifically designed for men on TRT. For years women have had supplements designed in much weaker formulas with only one or two of these natural estrogen supplements. But no one ever had the idea to create a powerful estrogen controlling supplement with clinical doses of all four of these natural supplements in one bottle.

NO AI vs Arimidex (Aromatase Inhibitors)

There is no question that Arimidex & Aromasin work to lower estrogen levels in men and women. This is literally why they were created and approved by the FDA. As we mentioned in our other article covering Aromatase Inhibitors, these medicines were created to nearly eradicate estrogen from the bodies of female patients with hormone reactive breast cancers.

Men on TRT do not need to try and get their estrogen levels to almost zero. They are usually trying to lower their estrogen levels 10 or 20 points to get back to or near to the reference range. So why take a medicine that is designed to eradicate all of your estrogen?

Is it a smart idea to take low dose cancer medication for the rest of your life when a natural supplement with possible health benefits is readily available? In our eyes we feel that you should at least try an natural supplement to help manage your estrogen levels while on testosterone replacement therapy before jumping to cancer medication that is extremely hard to dose, may weaken bones over time and may add to the negative effect that testosterone has on your cholesterol levels.

No AI is 100% natural and all four of the ingredients have been clinically shown to help manage estrogen levels. Did we mention that we also included a Patented Pepper Extract that has been shown to help improve oral bioavailability for many natural supplements? (Oral Bioavailability is the amount of the supplement that is able to be absorbed into the body through the stomach. The higher the bioavailability the more of the supplement your body can use.)

In our eyes NO AI is the clear winner as the best estrogen management supplement for men on TRT. But hey, we sell the stuff so of course we would say that. But when your only competition is a breast cancer medication that dissolves bones, lowers good cholesterol and raises bad cholesterol, it's not that hard to say!

You could also go spend over $100 on Amazon buying each of these estrogen management supplements separately and start taking 12 different pills a day. But why would you do that when we literally created the perfect estrogen lowering supplement in the perfect clinical dosages with the added benefit of a patented extract that has been shown to significantly increase oral bioavailability of so many natural supplements?

If you are ready to put the cancer medication down and harness the power of mother nature to help manage your estrogen levels on TRT, then get some NO AI and stop worrying about the long term effects of Arimidex and Aromasin!

No AI Estrogen Management Supplement for Men - 100% Natural

No AI Estrogen Management Supplement for Men - 100% Natural